Acute Promyelocytic Leukemia: Molecular Genetics, Mouse by Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)

By Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)

During the last 10 years, paintings on acute promyelocytic leukemia (APL) has turn into the paradigm of translational learn that started with the invention of a recurrent chromosomal translocation, via the identity of the genes and proteins concerned, discovering their molecular features in transcriptional keep watch over, developing mouse versions and culminating within the improvement  of specific remedy.

Show description

Read Online or Download Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313) PDF

Similar microbiology books

Chemolithoautotrophic Bacteria: Biochemistry and Environmental Biology

Micro organism swap the outside of the Earth. every kind of micro organism stay within the biosphere, and even supposing occasionally they might reason harm, in addition they assist in cleansing the skin of the Earth and within the circulate of varied ingredients. Chemolithoautotrophic micro organism particularly have a distinct and intimate dating with inorganic components and humans.

Parasit-Wirt-Beziehungen: Einfuhrung in die okologische Parasitologie

Parasiten sind uns nicht angenehm, denn sie leben auf Kosten anderer. Betrachtet guy aber den Wirtsorganismus als enge ökologische Nische, so findet guy faszinierende Anpassungen an den Lebensraum in und auf einem fremden Lebewesen. Diese vielfältigen Überlebensstrategien mußten auch Parasiten im Laufe der Evolution entwickeln.

Zoonotic Viruses of Northern Eurasia: Taxonomy and Ecology

Zoonotic Viruses of Northern Eurasia: Taxonomy and Ecology presents a overview of recent facts of the taxonomy, distribution, and ecology of zoonotic viruses within the ecosystems of Northern Eurasia. With weather adjustments, expanding inhabitants density of arthropod vectors and vertebrate hosts, improvement of unused lands, transferences of viruses by way of birds, bats, contaminated people, and animals, vectors let virus populations to evolve to the hot atmosphere.

Hydrocarbon and Lipid Microbiology Protocols: Genetic, Genomic and System Analyses of Communities

This quantity offers protocols for investigating the genetic, metabolic and ecological power and sensible research of microbial groups. tools are defined for the construction and bioinformatic overview of metagenomic and metatranscriptomic libraries, and for metaproteomic analyses, which supply very important insights into the metabolic power and interactions of neighborhood individuals.

Additional info for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313)

Sample text

Animal models of leukemia can be used to assess the potential role of the immune system in controlling malignant cell growth, and to examine strategies to boost the immune response to AML. The use of mouse models in which the leukemic oncoproteins are themselves expressed from murine genes may enhance the relevance of such studies to future human clinical investigation. 2. APL models have been used in preclinical studies to assess the potential value of new AML therapies. 3. Many agents that enter human clinical trials are initially assessed as single agent therapies in phase I trials.

2001). In this model, oral ATRA administration at the dose used had a moderate effect on subcutaneous growth of NB4 cells, and although NB4 cells are sensitive to ATRA, ATRA did not prolong survival of mice that received NB4 cells intravenously. The addition of the histone deacetylase inhibitor FK228 (also known as depsipeptide) to ATRA strongly suppressed subcutaneous growth. Further, when NB4 cells were injected intravenously, 3 of 7 dual-treated mice experienced long-term survival, in contrast to untreated or single-agent-treated animals.

A few cases also had Auer rods. Like the usual cases of APL, the promyelocytes were CD34− /CD13+ /CD33+ but were sometimes positive for the CD56 natural killer (NK) cell antigen. It was proposed that due to their characteristic regular nuclei and unusual immunophenotype, cases of APL with t(11;17)(q23;q21) should be given the subclassification M3r [69]. The PLZF gene is located on chromosome 11q23, about 1 Mb centromeric to the MLL (mixed lineage leukemia) gene. The PLZF locus was completely 32 M.

Download PDF sample

Rated 4.04 of 5 – based on 24 votes