Adenoviral Vectors for Gene Therapy by David T. Curiel (Editor), Joanne T. Douglas (Editor)

By David T. Curiel (Editor), Joanne T. Douglas (Editor)

Adenoviral Vectors for Gene remedy offers distinct and accomplished insurance of those vital healing brokers. the subjects coated during this publication variety from the elemental biology of adenoviruses, throughout the development and purification of adenoviral vectors, state-of-the-art vectorology and using adenoviral vectors in preclinical animal types, to regulatory matters which has to be thought of sooner than the initiation of human scientific gene remedy trials. The vast scope of this certain quantity presents the reader with an entire knowing of the improvement and use of adenoviral vectors. Key beneficial properties* offers whole assurance of simple biology of adenoviruses, in addition to the development, propagation and purification of adenoviral vectors* Introduces universal recommendations for the improvement of adenoviral vectors in addition to state-of-the-art tools for his or her development* Demonstrates noninvasive imaging of adenovirus-mediated gene move* Discusses application of adenoviral vectors in animal ailment types* Considers Federal Drug management laws for human scientific trials

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And Nemerow, G. R. (1999). /. Virol. 73, 1601-1608. 34. Stewart, P. , Ghiu, G. , and Nemerow, G. R. (1997). Gryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization. EMBO J. 16, 1189-1198. 35. Gepko, G. , and Sharp, P. A. (1982). Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell 31, 407-415. 36. , and Schnurr, D. P. (1996). /. Virol. 70, 1836-1844. 37. , and Philipson, L. (1980). Limited proteolysis and a reactive cysteine residue define accessible regions in the native conformation of the adenovirus hexon protein.

Finch, J. , De Rosier, D. , and Klug, A. (1970). Three dimensional reconstructions of spherical viruses by Fourier synthesis from electron micrographs. Nature 226, 421-425. 28. , Orlova, E. , and Schatz, M. (1996). A nev^ generation of the IMAGIC image processing system. /. Struct. Biol. 116, 17-24. 16 Phoebe L. Stewart 29. Ruigrok, R. , Albiges-Rizo, C , and Dayan, S. (1990). Structure of adenovirus fibre. II. /. MoL Biol. 215, 589-596. 30. Green, N. , Wrigley, N. , Russell, W. , Martin, S. , and McLachlan, A.

Maheshawri et al. have also shown that conjugation of RGD peptides on a synthetic substrate with an average spacing of 50 A allows efficient integrin-mediated cell motility [85]. Integrin clustering is intimately associated with signaling processes and actin rearrangement required for efficient virus entry (discussed below). C. Signaling Events Associated with Adenovirus Internalization Association of cell integrins such as avp3 with the extracellular matrix induces the formation of focal adhesion complexes.

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