Advances in Gene Delivery Systems by Kenya Kamimura; Takeshi Suda; Guisheng Zhang; Dexi Liu

By Kenya Kamimura; Takeshi Suda; Guisheng Zhang; Dexi Liu

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111-126. 16. , 1992, Local enhanced topical delivery of drugs: Does it truly exist? Pharm. Res. 9: 1422-1427. 17. Pharm. Sci. 81:601-602. 18. , 1982, Percutaneous absorption and anti-inflammatory activity of indomethacin in ointment, J. Pharm. Pharmacol. 34:467468. 19. , 1988, Anti-inflammatory activity of piroxicam after oral and topical administration on an ultraviolet-induced erythema model in man, Curr. Ther. Res. 44:340-347. 20. , 1983, Drug delivery to local subcutaneous structures following topical administration,}.

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Now consider finite dose conditions, when the chemical no longer covers the entire surface of the test area. The evaporation rate will be determined by many factors, including the rate of skin absorption. Compared to infinite dose conditions, the evaporation rate will begin to decrease with time (t) in proportion to the amount of chemical remaining on the skin surface. Ignoring skin absorption, the evaporation rate may be predicted by the following exponential equation: Evaporation Rate (finite dose) = A (e- kt ) (2) where A is the evaporation rate at t = 0 and k is a constant.

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