By F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)
F. M. MUGGIA whilst confronted with the inadequacies of present melanoma therapy, we wish to examine what the long run might carry. in most cases, we take without any consideration the previous, who prefer study into completely new parts. even if, the chronic improvement of fertile soil may well yield awesome rewards if you decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics. even if the anthracycline antibiotics symbolize a lot of the current and way forward for melanoma therapy, their genuine use c stretches again slightly 20 years to the pioneering efforts of Aurelio Di Marco, who characterised the antitumor houses of daunomycin and adriamycin. * The medical software of those compounds heralded a decade of pleasure between oncologists facing pediatric tumors, breast melanoma, leukemias, and lymphomas, and opened new wish for sufferers with sar comas and a number of different tumors that have been deemed - sistant to chemotherapy. those successes have been tempered with the belief that the antitumor impression of anthracyclines will be completed every now and then merely on the very excessive fee of risking cardiac decompensation and, virtually always, with the incidence of alopecia and different acute toxicities. This list of prior achievements and difficulties has slowly given method to a gift more and more illuminated by means of our skill to change the distressing toxicities of those brokers. specific scientific reports supplemented by means of creative laboratory versions have progressively elucidated mechanisms and threat elements im plicated within the cardiomyopathy.
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Additional info for Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981
Tological malignancies. , giving a disseminated disease. Our results have shown that both DNR and DX have a high antileukemic activity, which depends on the schedule of treatment \2). 3. ANTITUMOR ACTIVITY OF SELECTED ANTHRACYCLINE ANALOGS The preclinical tests conducted to date for experimental evaluation of anthracycline analogs have been previously reviewed (2). As regards antitumor activity, the general approach to these studies was to set up experimental models which could allow the identification of new anthracycline analogs having in respect to the parent compounds, either greater antitumor activity against tumors already sensitive to anthracyclines, or activity against tumors with natural or acquired resistance.
51. Skipper HE, Schabel FM, Lloyd HL. 1979. Adv. ' 205. 52. Arcamone F, Penco S, Redaelli S. 1976. J. Med. , ~, 1424. 53. Casazza AM, Bellini 0, Savi G, Di Marco A. 1981. Proc .. Am. Ass. , ~, 267. 54. Giuliani FC, Zirvi KA, Kaplan NO, Goldin A. 1981. Int. J. Cancer, ~, 5. 55. , Casazza AM, Giuliani F. 1981. ), ~, 183. 56. Casazza AM, Savi G, Pratesi G. 1981. 12th Int. , Florence, July 19-24, 1981, Abstracts, 73. 57. Giuliani FC, Coirin AK, Rice MR, Kaplan NO. Cancer Treat. Rep. (in press). 58.
Lenaz, International Div. , USA)proved to be mutagenic in strains TA98 and TA100 of Salmonella typh. with and without addition of rat liver S9. 4. Marcellomycin Marcellomycin is a new anthracycline antitumor antibiotic. We found this agent to be non-mutagenic in strains TA98 and TA100 of Salmonella typh. with and without addition of rat liver S9 (Table 14). Table 14. Surv. /Plate -S9 +S9 17 16 20 14 13 2 325 124 84 75 26 23 28 15 19 20 27 813 118 90 89 74 - >1,000 Procedures according to reference no.