Antibacterial Agents: Chemistry, Mode of Action, Mechanisms by Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

By Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

Antibacterial brokers act opposed to bacterial an infection both via killing the bacterium or by means of arresting its progress. They do that via focusing on bacterial DNA and its linked procedures, attacking bacterial metabolic strategies together with protein synthesis, or interfering with bacterial cellphone wall synthesis and function.

Antibacterial Agents is a necessary consultant to this crucial classification of chemotherapeutic medications. Compounds are organised in response to their objective, which is helping the reader comprehend the mechanism of motion of those medications and the way resistance can come up. The booklet makes use of an built-in “lab-to-clinic” method which covers drug discovery, resource or synthesis, mode of motion, mechanisms of resistance, scientific elements (including hyperlinks to present guidance, major drug interactions, cautions and contraindications), prodrugs and destiny improvements.

Agents lined include:

  • agents focusing on DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
  • agents concentrating on metabolic approaches -  sulfonamide antibacterial brokers and trimethoprim
  • agents concentrating on protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
  • agents focusing on phone wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin

Antibacterial Agents will discover a position at the bookshelves of scholars of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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Additional info for Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

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6, what will be the next amino acid in the protein after proline? (3) What is the codon (mRNA) and anticodon (tRNA) for each of the following: * tryptophan; * glycine; * STOP. (4) The discovery of new classes of selective antibacterial agents is partly dependent upon the identification of specific new bacterial targets. Within this section there is a reference to an enzyme which could be such a target for which there are no inhibitors currently in clinical use. Did you spot the enzyme? (5) Would Staphylococcus aureus: * be Gram positive or negative?

12 An integron is a genetic element that possesses a site at which further DNA, in the form of gene cassettes (usually linear sequences of a larger DNA molecule, such as a bacterial chromosome), can be integrated by site-specific recombination. It also encodes an enzyme – integrase – which mediates this site-specific recombination. 7 The ‘post-antibiotic age’? As mentioned in the previous subsection, and as we will see throughout this textbook, bacteria have remarkable ability to develop resistance to the antibacterial agents with which they are treated.

Between 1992 and 1997, 56% of all antibiotics employed annually in Australia were used in feedstock). Avoparcin, a vancomycin analogue, was used as a growth promoter in pig feedstock, but was withdrawn from the market when a link was discovered between its use and the emergence of Enterococcus faecium expressing the vanA gene. The mass exposure of farm animals to antibiotics has probably been a key factor in the rapid emergence of resistance in some drug classes and the transfer of resistant bacteria to humans through the food chain (Turnidge, 2001).

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