Antiepileptic drugs: combination therapy and interactions by Jerzy Majkowski,NetLibrary, Inc.

By Jerzy Majkowski,NetLibrary, Inc.

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These include the conversion of PRM to PB in much greater proportion when co-administered with PHT. The consequence is that giving PRM in such a combination essentially means the PRM is little more than a more costly pro-drug for PB. CBZ is metabolized into the 10–11 epoxide (CBZ-E), a pharmacodynamically active product. The quantities are usually sufficiently low to be of minimal clinical effect when CBZ is used as monotherapy. When PHT is co-administered, the conversion to CBZ-E is enhanced. If VPA is combined with CBZ, inhibition of CBZ-E hydrolase occurs and levels of the CBZ-E may rise to clinically meaningful amounts.

Yahr MD, Sciarra D, Carter S, et al. Evaluation of standard anticonvulsant therapy in three hundred nineteen patients. JAMA 1953; 150: 663–667. 3 Pharmacogenetic aspects Matthew C. Walker1, Michael R. Johnson2 and Philip N. Patsalos1 1 Pharmacology and Therapeutic Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, UK 2 Division of Neurosciences and Psychological Medicine, Imperial College London, Charing Cross Hospital, London, UK Introduction Pharmacogenetics and pharmacogenomics are fields which show how the genetic make-up of an individual can influence drugs effects.

The treatment of diabetes mellitus with oral hypoglycaemic drugs. Curr Med Drug 1965; 5: 23–32. Encyclopaedia Britannica on CD ROM, Multimedia Edition. 1999. Fincke BG, Miller DR, Spiro A III. The interaction of patient perception of overmedication with drug compliance and side effects. J Gen Intern Med 1998; 13: 182–185. Freestone DS. Formulation and therapeutic efficacy of drugs used in clinical trials. Lancet 1969; 2: 98–99. 13 Combination therapy of diseases: general concepts Frishman WH. Mibefradil: A new selective T-channel calcium antagonist for hypertension and angina pectoris.

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