Aplastic Anemia: Pathophysiology and Approaches to Therapy by H. Heimpel (auth.), Hermann Heimpel M. D., Edward C.

By H. Heimpel (auth.), Hermann Heimpel M. D., Edward C. Gordon-Smith M. D., Wolfgang Heit M. D., Bernhard Kubanek M. D. (eds.)

Research on aplastic anaemia has till lately been restricted to medical description, morphology and epidemiology. New how you can tradition haemopoietic cells, and advances in our wisdom of proliferation and differentiation within the haemopoietic telephone approach .opened a brand new quarter of medical curiosity for this "prototype" of haemopoietic failure. furthermore, bone marrow transplantation turned not just a scientific approach to remedy, but additionally a resource of knowledge important for the dialogue of pathophysiological versions of aplastic anaemia. this example triggered us to rearrange a global con­ ference on aplastic anaemia, with specific emphasis on its patho­ body structure and the rationals of the present healing methods. This convention was once held at Schloss Reisensburg from July 20-22, 1978 with the participation of either experimental and scientific scientists lively during this box or in comparable components of analysis. The complaints of the symposion mirror the current wisdom in addition to the numerous new questions which arose from the discussions. The editors are gratefully indebted to the members of this assembly, to Gerlinde Trogele and the entire co-workers of the Uni­ versity of Ulm engaged in coaching of this symposium and of this quantity, and final no longer least to all sponsors who supplied the monetary foundation for this medical event.

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Van Doornik, M. , van t'Veer, E. : Fatal aplastic anemia complicating infectious mononucleosis. Scand. J. Haematol. 20, 52-56 (1978) 9. , Hosokawa, K. : Clinicogenetic Studies on Hypoplastic Anemia. In: Aplastic Anemia. Proceedings of the First International Symposium on Aplastic Anemia, Kyoto 1976. ). Tokyo: University of Tokyo Press, 1978, pp. 185-188 10. Komiya, M. : see 2. Aoki et al. 11. , Shani, M. : Aplastic anemia in Israel: Evaluation of the aetiological role of chloramphenicol on a community-wide basis.

Medearis, D. N. , Osborn, J. : Blood and bone marrow findings in congenital rubella. J. Pediatr. 5 Aplastic Anemia Terminating in Leukemia K. P. Hellriegel, 1. Fohlmeister, H. E. Schaefer Aplastic anemia is characterized by well defined clinical and morphological features, although there are fundamental differences in pathogenesis. The cardinal symptom of aplastic anemia, that of bone marrow aplasia, may be constitutional, induced by radiation or cytostatics, by certain drugs, or even due to agranulocytosis; and in some cases its origin may be unknown.

Of patients Oxyphenbutazone (Tanderil) 10 Chloramphenicol 5 Phenylbutazone (Butazolidin) 4 2 Sulfonamides Metamizol (Dipyrone, Novalgin) Ampicillin Trimetadione Indomethacin Doxycycline Griseofulvin Amytryptiline Diphenyldydantoine 29 Whereof deaths Table 5. Drugs causing aplastic anemia in Sweden (1966-70) 5 4 2 1 1 1 19 66% demonstrate that the risk in the beginning was grossly underestimated. Four separate studies of the risk of getting chloramphenicol-induced aplastic anemia have been summarized in Figure 3.

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