Application of Hyperthermia in the Treatment of Cancer by S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels,

By S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, Prof. Dr. med. Wolfgang Wilmanns (eds.)

Physicians, biologists and physicists current their fresh paintings within the box of hyperthermia with reference to either its software and its mix with radiation and chemotherapy. present technical chances, scientific administration and significant points of its use for superficial and deep-seated tumors are mentioned. the most themes mentioned are: adjustments of metabolism and microcirculation below warmth stipulations, the organic interplay of warmth with X-rays and a number of other chemotherapeutic brokers, and the newest medical info from diversified associations at the mixed software within the remedy of cancer.

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An example of this is shown in Fig. 7. No explanation for this phenomenon has yet been offered, although several authors, including Vaupel et al. (1983) report the development of oedema in the tumour interstitium during hyperthermic treatment. One would, however, in that case expect some correlation between the circulation parameters and the volume increase, but such correlation is presently lacking (Reinhold 1987, unpublished material). Another factor that may be very important is that the arterial venous pressure gradient over the tumour tends to decrease with hyperthermia.

Most cellular glutathione exists in the reduced thiol form (GSH), although various mixed disulfides, thioester and to a lesser extent glutathione disulfide (GSSG) contribute to the total cellular pool of glutathione. GSH is known to protect against oxygen-induced free radicals and peroxides that are normally produced in small amounts as a result of oxygen metabolism (Chance et al. 1979). The depletion of cellular GSH by inhibition of y-glutamylcysteine synthetase might make tumour cells more susceptible to radiation and chemotherapeutic agents (Meister and Griffith 1979; Dethmers and Meister 1981).

Note that after a given temperature dose (in this instance consisting of a gradual increase to 47° Cover 65 min) the flux sharply declines. This indicates a sudden, complete vascular collapse be observed. Nonetheless, it has been shown possible to derive the Arrhenius slope for this effect (Fig. 4). 4 were calculated with statistical methods based on estimation of the probability of events happening, in this case the failure rate of the microcirculation. This is the general way of handling such data in cellular biology, radiobiology and tumour biology.

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